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KMID : 0861120130170010117
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Korean Journal of Oriental Preventive Medicine
2013 Volume.17 No. 1 p.117 ~ p.124
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A Study on the Acute Toxicity of Palmultang and Fermented Palmultang Extract in ICR Mice
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Jung Ki-Youn
Hwang Youn-Hwan
Jang Doo-Rye
Ha Jeong-Ho
Ma Jin-Yeul
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Abstract
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Objectives : This study was carried out to investigate the acute toxicity and safety of Palmultang and Fermented Palmultang Extract in Mice.
Methods : To evaluate their acute toxicity and safety, 0 (control group), 2000 ㎎/㎏ of Palmultang and Fermented Palmultang Extracts were orally administered to 15 male and 15 female ICR mice. After a single administration, we observed survival rates, behavioral pattern, clinical sign, body weight. The results of biochemical analysis and hematological analysis were no any significant change.
Results : Compared with the control group, we could not find any toxic alteration in all treated mice.
Conclusions : Overall, the results suggest that, the oral administration of Palmultang and Fermented Palmultang extracts did not produce significant toxic effect in mice. Hence, the fermented extract can be utilized for herbal therapy.
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KEYWORD
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Palmultang, Acute toxicity, Fermentation, Safety, LD50
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